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Distribution of tumor-infiltrating immune cells in glioblastoma
dc.contributor.author | Castaneda, Carlos A. | |
dc.date.accessioned | 2020-03-27T22:33:24Z | |
dc.date.available | 2020-03-27T22:33:24Z | |
dc.date.issued | 2018 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14308/2646 | |
dc.description.abstract | Aim: Evaluation of features related to infiltrating immune cell level in glioblastoma. Methods: Tumor- infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage (CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis. Results: CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest density. Higher CD4 + was as- sociated with unmethylated MGMT (p = 0.016). Higher CD8 + was associated with larger tumoral size (p = 0.027). Higher CD163 + was associated with higher age (p = 0.044) and recursive partitioning anal- ysis = 4. Women (p < 0.05), total resection (p < 0.05), MGMT-methylation (p < 0.001), radiotherapy (p < 0.001), chemotherapy (p < 0.001) and lower CD4 + (p < 0.05) were associated with longer overall survival. Conclusion: Macrophages are more frequent than TILs. Some subsets are associated with clinical features. | es_PE |
dc.format | application/pdf | es_PE |
dc.language.iso | eng | es_PE |
dc.publisher | CNS Oncology | es_PE |
dc.rights | info:eu-repo/semantics/openAccess | es_PE |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | Universidad Privada San Juan Bautista | es_PE |
dc.source | Repositorio institucional - UPSJB | es_PE |
dc.subject | Biomarcador | es_PE |
dc.subject | Glioblastoma | es_PE |
dc.subject | Macrófagos | es_PE |
dc.subject | MGMT | es_PE |
dc.subject | Supervivencia general | es_PE |
dc.subject | Pronóstico | es_PE |
dc.subject | Infiltración tumoral linfocitos | es_PE |
dc.title | Distribution of tumor-infiltrating immune cells in glioblastoma | es_PE |
dc.type | info:eu-repo/semantics/article | es_PE |
dc.publisher.country | PE |