Association Between Periodontal Disease and the Risk of COVID-19 Complications and Mortality: A Systematic Review
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Fecha
2021-08-28Autor(es)
Espinoza-Espinoza1, Daniel Alonso Kim
Dulanto-Vargas1, Julissa Amparo
Cáceres-LaTorre1, 1 , Oswaldo Andreé
Lamas-Castillo2, Fiorella Estefanie
Flores-Mir3, Carlos
Cervantes-Ganoza4, Luis Adolfo
López-Gurreonero5, Carlos
Ladera-Castañeda6, Marysela Irene7,
Cayo-Rojas6, César Félix
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Aim: The COVID-19 pandemic has strained the world’s healthcare systems.
Studies have identified how the COVID-19 infections are linked to several
co-morbidities such as hypertension, diabetes, cardiovascular disease, renal and
pulmonary disease. It is known that periodontal disease (PD) shares the same
risk factors. Moreover, both diseases are characterized by an exaggerated immune
response. The aim of the study was to investigate the available evidence of a
potential association between PD and the risk of COVID-19 complications and
mortality. Materials and Methods: MEDLINE/PubMed, EMBASE, Scopus, and
ProQuest were searched. Studies that assess the association between PD and the
risk of COVID-19 complications and mortality were eligible for inclusion. Two
independent reviewers performed the selection of articles and data extraction.
The New Castle Ottawa Scale was used to assess the quality of the selected
studies, and the GRADE system was used to evaluate the level of confidence
to support the conclusions. Results: Only two studies met the eligibility criteria.
One study had a low risk of bias, whereas the other had a high risk of bias.
Conclusion: The level of confidence in the available evidence is very low. A close
association between periodontitis and the risk of COVID-19 complications and
mortality can neither be supported nor refuted.
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