Histologic findings and related diagnostic methods in condylar hyperactivity
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Date
2020Author(s)
Espinosa, Sebastián
Covarrubias, E.
Díaz, R.
Diaz Cavero, Karla Tatiana
Cafferata, Emilio A
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Condylar hyperactivity (CH) is a rare condition that entails a progressive
deviation and deformation of the mandible. There is no consensus regarding
characteristic histopathological features or a standardized diagnostic process; thus,
histopathological analysis of the condyle cannot confirm or exclude an active CH
after condylectomy is performed. An electronic search was performed in Medline,
Embase, Web of Science, LILACS and grey literature up to December 2019.
Additionally, a manual search was performed. Risk of bias of the included studies
was assessed using the Newcastle–Ottawa Scale and the Institute of Health
Economics Quality Appraisal. All analyses were performed independently and in
duplicate. Seventeen articles from 660 were included. Six articles were crosssectional
studies and 11 were case series. Almost all the articles (14) described an
augmented thickness of the cartilage layer associated with cartilage islands within
the subchondral bone in patients affected by CH. Histological findings seem to be
mostly related to the age of the sample rather than a characteristic description of CH.
No clear association was found between SPECT/scintigram uptake and a specific
histological finding. Hence, there is a necessity for the development of specific tools
for evaluating and reporting studies where histology is needed for diagnosis
confirmation
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