Assessment of Antibacterial and Antifungal Properties and In Vivo Cytotoxicity of Peruvian Passiflora Mollisima
Ver/
Descargar
(application/pdf: 646.8Kb)
(application/pdf: 646.8Kb)
Fecha
2019-02Autor(es)
Calderon, Adrián
Salas, Julio
Dapello, Giannina
Gamboa, Eloy
Rosas, José
Chávez, Juana
Retuerto, Fernando
Mayta-Tovalino, Frank
Metadatos
Mostrar el registro completo del ítemResumen
Aim: The antimicrobial activity of Passiflora mollissima is
largely due to its aliphatic and aromatic hydrocarbons, terpenes,
alkaloids, ketones, esters, alcohols, and lactones. The objective
of this research was to evaluate the antimicrobial activity of
the compounds in the Passiflora mollissima (Tumbo) fruit and
leaves included also on cultured strains of the microorganisms
Streptococcus mutans, Streptococcus oralis, Streptococcus
sanguinis and Candida albicans.
Materials and methods: Antimicrobial activity was analyzed
by the disk diffusion method and evaluated in terms of their
zones of inhibition. The cytotoxic activity of these compounds
was determined in a bioassay involving sea urchin eggs
(Tetrapygusniger) in which the inhibition percentage of artificially
fertilized ovules was equivalent to their cytotoxic activity
after 26 hours.
Results: This study demonstrated the antimicrobial activity
of ethanolicPassiflora mollissima extract against the cultured
strains of Streptococcus mutans, Streptococcus oralis, and
Streptococcus sanguinis with zones of inhibition after the
incubation period.
Conclusion: There was no evidence of activity against the
pathogenic Candida albicans, which demonstrates a null antifungal
capacity of the evaluated extracts. However, cytotoxic
activity was found, and the compounds led to the complete inhibition
of 100% of sea urchin ovules after 26 hours of exposure.
Palabras clave
Colecciones
El ítem tiene asociados los siguientes ficheros de licencia: