Distribution of tumor-infiltrating immune cells in glioblastoma
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2018Autor(es)
Castaneda, Carlos A.
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Aim: Evaluation of features related to infiltrating immune cell level in glioblastoma. Methods: Tumor-
infiltrating lymphocytes (TILs) through H&E staining, and TILs (CD3, CD4, CD8 and CD20) and macrophage
(CD68 and CD163) levels through immunohistochemistry were evaluated through digital analysis. Results:
CD68 (9.1%), CD163 (2.2%), CD3 (1.6%) and CD8 (1.6%) had the highest density. Higher CD4 + was as-
sociated with unmethylated MGMT (p = 0.016). Higher CD8 + was associated with larger tumoral size
(p = 0.027). Higher CD163 + was associated with higher age (p = 0.044) and recursive partitioning anal-
ysis = 4. Women (p < 0.05), total resection (p < 0.05), MGMT-methylation (p < 0.001), radiotherapy
(p < 0.001), chemotherapy (p < 0.001) and lower CD4 + (p < 0.05) were associated with longer overall
survival. Conclusion: Macrophages are more frequent than TILs. Some subsets are associated with clinical
features.
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